First insights into species and genotypes of Echinococcus in South Africa
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- 作者：Benjamin K. Mogoye ; Colin N. Menezes ; Michelle L. Wong ; Sarah Stacey ; Dirk von Delft ; Kerstin Wahlers ; Marion Wassermann ; Thomas Romig ; Peter Kern ; Martin P. Grobusch ; John Frean
- 关键词：Echinococcus granulosus ; Cystic echinococcosis ; Genotype ; Human ; Dog ; South Africa
- 刊名：Veterinary Parasitology
- 出版年：2013
- 出版时间：23 September, 2013
- 年：2013
- 卷：196
- 期：3-4
- 页码：427-432
- 全文大小：269 K
文摘
Cystic echinococcosis is a serious and neglected parasitic zoonosis that is regarded as an emerging disease world-wide. Effective control of the disease is based on understanding the variability of Echinococcus granulosus (sensu lato), as genotypic characteristics may influence lifecycle patterns, development rate, and transmission. No molecular epidemiological research has previously been conducted to shed light on genotypes responsible for the disease in South Africa. To identify strains circulating in the country, parasite material was collected from patients between August 2010 and September 2012 and analyzed by PCR/RFLP methods. A total of 32 samples was characterized as E. granulosus sensu stricto (G1-G3) (81 % ), E. canadensis (G6/7) (16 % ) and E. ortleppi (G5) (3 % ). Furthermore, two co-amplifying G6/7 genotypes were confirmed as G7 by sequencing. This is the first report on genotyping of Echinococcus species in South Africa, and, to the best of our knowledge, the first report of the G5 and G7 genotypes from humans in Africa.