An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4⁺ T-cells

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• 作者：Eufemia G.M. Berkhoff ; Martina M. Geelhoed-Mieras ; Marcel Jonges ; Derek J. Smith ; Ron A.M. Fouchier ; Albert D.M.E. Osterhaus ; Guus F. Rimmelzwaan
• 关键词：CD4⁺ T-cells ; Escape ; Influenza A virus
• 刊名：Virus Research
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：126
• 期：1-2
• 页码：282-287
• 全文大小：408 K

文摘

Influenza virus-specific CD4⁺ T-helper cells were cloned that recognized a virus strain isolated in 1981, but that failed to recognize more recent strains. The HLA-DR*1601-restricted epitope recognized was located in the hemagglutinin (HA_99–113) and the naturally occurring A → V substitution at position 106 was responsible for abrogating the recognition by HA_99–113-specific CD4⁺ T-cells. This amino acid substitution was found in influenza A/H3N2 viruses that circulated between 1999 and 2005 and did not affect recognition by virus-specific antibodies. It was speculated that influenza viruses could evade recognition by virus-specific CD4⁺ T-cells, at least temporarily.