Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients

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• 作者：Monika Martina Wö ; lfler^a ; Mareike Kü ; ppers^b ; Werner Rath^c ; Volker Uwe Buck^b ; Ivo Meinhold-Heerlein^c ; Irmgard Classen-Linke^b ; ^{iclassen-linke@ukaachen.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Endometriosis ; Eutopic endometrium ; PR-A/PR-B ; Immunohistochemistry ; Menstrual cycle
• 刊名：Annals of Anatomy - Anatomischer Anzeiger
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：206
• 期：Complete
• 页码：1-6
• 全文大小：2153 K

文摘

Recent data implicate an altered expression of progesterone receptor isoform A (PR-A) and B (PR-B) in the endometrium of endometriosis patients. This prospective exploratory study aimed to precisely determine the PR-A and PR-B expression using immunohistochemical techniques in eutopic endometrium of women with endometriosis compared with disease-free women throughout the menstrual cycle.

All symptomatic patients underwent laparoscopy for the diagnosis of endometriosis and histological confirmation of the disease (EO) whereas controls were proven disease-free (CO). In CO samples (n = 10) an increased expression of PR-A and PR-B during the proliferative to early secretory phase and a decreased expression of both receptor isoforms during the mid to late secretory phase was ascertained in accordance with previous studies.

In patients with endometriosis (n = 16) no cycle dependent pattern of PR-A and PR-B expression was identified in contrast to patients without endometriosis. Moreover, in EO samples a huge variety of inter- and intra-individual differences in PR-A and PR-B expression were detected.

These data provide further evidence that dysregulation of the PR-A and PR-B expression might contribute to the pathophysiology of endometriosis.