NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation
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- 作者：Sara Gallini1 ; Manuel Carminati1 ; Fabiola De Mattia2 ; Laura Pirovano1 ; Emanuele Martini3 ; 4 ; Amanda Oldani3 ; 4 ; Italia Anna Asteriti2 ; Giulia Guarguaglini2 ; giulia.guarguaglini@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Marina Mapelli1 ; marina.mapelli@ieo.eu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：22 February 2016
- 年：2016
- 卷：26
- 期：4
- 页码：458-469
- 全文大小：3457 K
文摘
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Aurora-A contributes to spindle orientation by controlling NuMA cortical targeting
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Phosphorylation of Ser1969NuMA by Aurora-A governs NuMA mobility at spindle poles
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NuMA residues 2002–2115 bind to microtubules, independently of Aurora-A
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NuMA binds simultaneously microtubules and the spindle orientation protein LGN