Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis
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- 作者：Eva Martini1 ; Nadine Wittkopf1 ; Claudia Gü ; nther1 ; Moritz Leppkes1 ; Hitoshi Okada2 ; Alastair J. Watson3 ; Eva Podstawa1 ; Ingo Backert1 ; Kerstin Amann4 ; Markus F. Neurath1 ; Christoph Becker1 ; christoph.becker@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：14
- 期：5
- 页码：1062-1073
- 全文大小：5828 K
文摘
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Survivin is expressed in stem and progenitor cells of the intestinal epithelium
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Deletion of Survivin in IECs leads to death of animals within a few days
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Survivin deletion induces loss of transit-amplifying cells and Lgr5+ stem cells
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Survivin-deficient cells show cell-cycle defects and signs of mitotic catastrophe