Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses

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• 作者：Miroslava Martinková ; ; ^{miroslava.martinkova@upjs.sk" class="auth_mail" title="E-mail the corresponding author} ; Jozef Gonda
• 关键词：Sphingolipids ; Anhydrophytosphingosines ; Jaspine B ; Cytotoxic activity ; Stereoselective synthesis ; Asymmetric synthesis
• 刊名：Carbohydrate Research
• 出版年：2016
• 出版时间：24 March 2016
• 年：2016
• 卷：423
• 期：Complete
• 页码：1-42
• 全文大小：8153 K

文摘

Conformationally constrained sphingolipids such as anhydrophytosphingosines represented by jaspine B (also known as pachastrissamine) and its stereoisomers have become an attractive and timely target for total synthesis due to their significant biological activity as well as the unique structures. This review article describes the biological activity and chemistry of the natural jaspine B and its seven stereoisomers.