Total synthesis and the anticancer activity of (+)-spisulosine
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- 作者：Milica Fabi&scaron ; í ; ková ; a ; Miroslava Martinková ; a ; miroslava.martinkova@upjs.sk" class="auth_mail" title="E-mail the corresponding author ; Simona Hirková ; a ; Jozef Gondaa ; Martina Bago Pilá ; tová ; b ; Gabriela Gö ; nciová ; b
- 关键词：1-deoxysphingoid bases ; Spisulosine ; [3 ; 3]-heterosigmatropic rearrangement ; Stereoselective synthesis ; Antiproliferative activity
- 刊名：Carbohydrate Research
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：435
- 期：Complete
- 页码：26-36
- 全文大小：1105 K
文摘
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The total synthesis of (+)-spisulosine.
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The substrate controlled [3,3]-sigmatropic rearrangement was employed as the key reaction.
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The cytotoxicity of the synthesized compounds was evaluated.