MK615 attenuates Porphyromonas gingivalis
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- 作者：Yoko Morimoto ; Kiyoshi Kikuchi ; Takashi Ito ; Masayuki Tokuda ; Takashi Matsuyama ; Satoshi Noma ; Teruto Hashiguchi ; Mitsuo Torii ; Ikuro Maruyama ; Ko-ichi Kawahara
- 关键词：MK615 ; Periodontitis ; Pro-inflammatory mediators ; NF-κ ; B
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2009
- 出版时间：6 November 2009
- 年：2009
- 卷：389
- 期：1
- 页码：90-94
- 全文大小：373 K
文摘
The Japanese apricot, known as Ume in Japanese, has been a traditional Japanese medicine for centuries, and is a familiar and commonly consumed food. The health benefits of Ume are now being widely recognized and have been strengthened by recent studies showing that MK615, an extract of compounds from Ume, has strong anticancer and anti-inflammatory effects. However, the potential role of MK615 in the periodontal field remains unknown. Here, we found that MK615 significantly reduced the production of pro-inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) induced by Porphyromonas gingivalis lipopolysaccharide (LPS), a major etiological agent in localized chronic periodontitis, in murine macrophage-like RAW264.7 cells. MK615 markedly inhibited the phosphorylation of ERK1/2, p38MAPK, and JNK, which is associated with pro-inflammatory mediator release pathways. Moreover, MK615 completely blocked LPS-triggered NF-κB activation. The present results suggest that MK615 has potential as a therapeutic agent for treating inflammatory diseases such as periodontitis.