Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders
Amygdala FxC in response to emotion processing is abnormal in youth with BPSD. Amygdala-VLPFC FxC to all emotions is positive in BPSD but inverse in HC and ADHD. Amygdala-subgenual FxC to negative emotions is positive in BPSD but inverse in HC. VLPFC findings are specific to BPSD, and not found in youth with ADHD. Subgenual FxC also varies with depression and stimulant medication.