Concomitant chronic myeloid leukemia and chronic lymphocytic leukemia: a different clonal origin shown by molecular cytogenetics
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- 作者：Aless ; ro Gozzetti ; Monica Bocchia ; Rosaria Crupi ; Simona Calabrese ; M.T. Pirrotta ; Donatella Raspadori ; Marzia Defina ; Renato Algeri ; Francesco Lauria
- 关键词：Foot burns ; Epidemilogy ; Treatment
- 刊名：Cancer Genetics and Cytogenetics
- 出版年：2008
- 出版时间：1 January 2008
- 年：2008
- 卷：180
- 期：1
- 页码：83-84
- 全文大小：121 K
文摘
Monosomy 21 is a rare acquired karyotypic abnormality associated with myeloid disorders. Occurrence of loss of one chromosome 21 in the background of trisomy 21 in Down syndrome, resulting in the pseudo-normalization of trisomy 21, is a novel finding. The case is described of a patient with Down syndrome who acquired such a genetic abnormality as a result of myelodysplastic syndrome.