Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells
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- 作者：Koumei Shirasunaa ; ks205312@nodai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroki Takanoa ; Kotomi Senoa ; Ayaka Ohtsua ; Tadayoshi Karasawab ; Masafumi Takahashib ; Akihide Ohkuchic ; Hirotada Suzukic ; Shigeki Matsubarac ; Hisataka Iwataa ; Takehito Kuwayamaa
- 关键词：Obesity ; Placenta ; Palmitic acid ; Inflammasome ; Reactive oxygen species
- 刊名：Journal of Reproductive Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：116
- 期：Complete
- 页码：104-112
- 全文大小：1591 K
文摘
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Palmitic acid activates of NLRP3 inflammasomes, resulting in IL-1β in human Sw.71 placental cells.
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Palmitic acid stimulates IL-6 and IL-8 secretion depending on caspase-3 activation.
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ROS production by palmitic acid is important in the induction of inflammatory responses.