Does veno-arterial bypass without an artificial lung improve the outcome in dogs undergoing cardiac arrest?

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• 作者：Yoshitake ; Atsushi ; Tanimoto ; Hironari ; Ao ; Hushan ; Ichinose ; Keisuke ; Tashiro ; Masafumi ; Sakanashi ; Yuji ; et. al.
• 关键词：Anoxia ; Cardiac arrest ; Cardiopulmonary bypass ; Cardiopulmonary resuscitation ; Outcome ; Return of spontaneous circulation ; Anó ; xia ; Paragem cardí ; aca ; bypass cardiopulmonar ; Ressuscitaç ; ã ; o cardiopulmonar ; Resultado ; Retorno de cir
• 刊名：Resuscitation
• 出版年：2002
• 出版时间：August 1, 2002
• 年：2002
• 卷：54
• 期：2
• 页码：159-166
• 全文大小：169 K

文摘

We hypothesized that maintaining circulation and blood pressure by veno-arterial bypass (V-A bypass) without oxygenation would improve cardiopulmonary resuscitation (CPR) and survival rates. A total of 32 dogs, divided into four groups, were subjected to normothermic ventricular fibrillation (VF) for 15 min. The method of CPR was the same in the four groups, except for the method and timing of V-A bypass. We attempted to resuscitate the dogs without V-A bypass (control), with V-A bypass not including an artificial lung during VF, with V-A bypass not including an artificial lung during CPR, and with V-A bypass including an artificial lung during CPR. CPR was continued until restoration of spontaneous circulation (ROSC) or for 30 min. Although blood pressure was well maintained, severe hypoxemia was observed during V-A bypass without an artificial lung. The resultant hypoxemia was very detrimental. ROSC was achieved more easily in all dogs in the bypass group with an artificial lung. No significant difference in survival rates was demonstrated among the four groups (P