Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

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• 作者：Masahiro Maruyama ; Hitoshi Shimada ; Tetsuya Suhara ; Hitoshi Shinotoh ; Bin Ji ; Jun Maeda ; Ming-Rong Zhang ; John?Q. Trojanowski ; Virginia?M.-Y. Lee ; Maiko Ono ; Kazuto Masamoto ; Harumasa Takano ; Naruhiko Sahara ; Nobuhisa Iwata ; Nobuyuki Okamura ; Shozo Furumoto ; Yukitsuka Kudo ; Qing Chang ; Takaomi?C. Saido ; Akihiko Takashima ; et al.
• 刊名：Neuron
• 出版年：2013
• 出版时间：18 September, 2013
• 年：2013
• 卷：79
• 期：6
• 页码：1094-1108
• 全文大小：5937 K

文摘

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Summary

Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer¡¯s disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders. In?vivo optical and positron emission tomographic (PET) imaging of a transgenic mouse model demonstrated sensitive detection of?tau inclusions by PBBs. A pyridinated PBB, [¹¹C]PBB3, was next applied in a clinical PET study, and its robust signal in the AD hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [¹¹C]Pittsburgh Compound-B ([¹¹C]PIB). [¹¹C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [¹¹C]PBB3 signals were found in a corticobasal syndrome patient negative for [¹¹C]PIB-PET.