Enantioselective total synthesis of heliespirone B

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• 作者：Akari Miyawaki ; Yuki Manabe ; Masahiro Yoshida ; Kozo Shishido ; ^{shishido@ph.tokushima-u.ac.jp}
• 关键词：Total synthesis ; Heliespirone B ; Intramolecular oxy-Michael reaction ; Regioselective reduction ; Diastereoselective reduction
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：7 March, 2012
• 年：2012
• 卷：53
• 期：10
• 页码：1236-1239
• 全文大小：489 K

文摘

The first enantiocontrolled total synthesis of heliespirone B has been accomplished employing a biomimetic intramolecular oxy-Michael reaction followed by the regio- and diastereoselective reduction of the carbonyl function as key steps.