Expression of TGF-βs and TGF-β type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus

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• 作者：Xianfeng Li ; Masakazu Miyajima ; Chuanlu Jiang ; Hajime Arai
• 关键词：Cerebrospinal fluid ; ELISA ; Idiopathic normal pressure hydrocephalus ; TGF-β
• 刊名：Neuroscience Letters
• 出版年：2007
• 出版时间：14 February 2007
• 年：2007
• 卷：413
• 期：2
• 页码：141-144
• 全文大小：151 K

文摘

We investigated cerebrospinal fluid (CSF) samples from 21 patients with idiopathic normal pressure hydrocephalus (INPH) and 14 controls without neurological disease. The concentrations of leucine-rich α-2-glycoprotein (LRG), transforming growth factor (TGF)-β1, 2, 3 and TGF-β type II receptor (TβR-II) in CSF were measured using ELISA. TGF-β1, TβR-II and LRG CSF levels of patients with INPH were significantly higher than controls, whereas no significant differences in TGF-β2 levels were found between INPH patients and controls. The present study suggests that TGF-βs expressions may be modulated differently in patients with INPH. These results also indicate that the CSF level assay of TGF-β1, TβR-II and LRG is useful for the diagnosis of patients with INPH, and TGF-β1, TβR-II and LRG may be involved in the pathogenesis of the disease.