An immunohistochemical study of placental syncytiotrophoblasts in neonatal hemochromatosis
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- 作者：Aiko Shimonoa ; 1 ; 2 ; Yuko Imotoa ; 1 ; 3 ; Haruhiko Sakamotoa ; profsaka@med.kagawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoichi Chibaa ; Koichi Matsumotoa ; Machi Kawauchia ; Takashi Kusakab ; Hirokazu Tanakac ; Toshiyuki Hatac ; Yoshio Kushidad ; Masaki Uenoa
- 关键词：Iron ; Transferrin receptor 1 ; Ferroportin ; Hepcidin ; Liver cirrhosis ; Immunohistochemsitry
- 刊名：Placenta
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：49-55
- 全文大小：2069 K
文摘
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In neonatal hemochromatosis (NH), immunohistochemistry of the placenta revealed increased expressions of transferrin receptor 1 (TFR1), transferrin, ferritin, hepcidin, divalent metal transporter 1, and HFE on the microvillar surface, and TFR1, hepcidin, hephaestin, and HFE in the cytoplasm of syncytiotrophoblasts (STB).
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Increased expression of TFR1 on the surface of STB in NH is prominent and may primarily contribute to the increased influx of iron from the mother to fetus.
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It is suggested that hepcidin on the surface and in the cytoplasm of STB derives from the mother in NH.