Neuronal Regulation of Schwann Cell Mitochondrial Ca2+ Signaling during Myelination
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- 作者：Daisuke Ino1 ; Hiroshi Sagara2 ; Junji Suzuki1 ; Kazunori Kanemaru1 ; Yohei Okubo1 ; Masamitsu Iino1 ; iino@m.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 September 2015
- 年：2015
- 卷：12
- 期：12
- 页码：1951-1959
- 全文大小：3387 K
文摘
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A purinergic agonist stimulates mitochondrial metabolism in Schwann cells (SCs)
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Firing peripheral nervous system axons release ATP to the extracellular space
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ATP released from firing axons activates the P2RY2-IP3-MCU pathway in myelinating SCs
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Suppression of the P2RY2-IP3-MCU pathway in myelinating SCs causes hypomyelination