Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum
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- 作者：Itoigawa ; Masataka ; Ito ; Chihiro ; Tan ; Hugh T.-W. ; Kuchide ; Masashi ; Tokuda ; Harukuni ; Nishino ; Hoyoku ; et. al.
- 关键词：4-Phenylcoumarins ; Cancer chemopreventive agents ; Anti-tumor-promoting effect ; Epstein&ndash ; Barr virus activation ; Two-stage mouse skin carcinogenesis ; Calophyllum inophyllum
- 刊名：Cancer Letters
- 出版年：2001
- 出版时间：August 10, 2001
- 年：2001
- 卷：169
- 期：1
- 页码：15-19
- 全文大小：151 K
文摘
In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters).