Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants
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- 作者：Itoigawa ; Masataka ; Ito ; Chihiro ; Tan ; Hugh T.-W. ; Okuda ; Masato ; Tokuda ; Harukuni ; Nishino ; Hoyoku ; et. al.
- 关键词：Naphthoquinones ; Cancer chemopreventive agents ; Anti-tumor-promoting effect ; Epstein&ndash ; Barr virus activation ; Two-stage mouse skin carcinogenesis ; Avicennia plants
- 刊名：Cancer Letters
- 出版年：2001
- 出版时间：December 28, 2001
- 年：2001
- 卷：174
- 期：2
- 页码：135-139
- 全文大小：97.3 K
文摘
As a part of screening studies for cancer chemopreventive agents (anti-tumor promoters), six natural and four synthetic naphthoquinones and five of their analogs were tested for their inhibitory activities against Epstein–Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxicity. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-ring, displayed the most potent activity. Furthermore, avicenol-A (9) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these 1,4-naphthoquinones and their analogs might be valuable as potent cancer chemopreventive agents.