Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants
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- 作者：Itoigawa ; Masataka ; Ito ; Chihiro ; Tokuda ; Harukuni ; Enjo ; Fumio ; Nishino ; Hoyoku ; Furukawa ; Hiroshi
- 关键词：Phenylpropanoids ; Phytoquinoids ; Illicium ; Cancer chemopreventive activity ; Anti-tumor promoter ; Epstein&ndash ; Barr virus activation test
- 刊名：Cancer Letters
- 出版年：2004
- 出版时间：October 28, 2004
- 年：2004
- 卷：214
- 期：2
- 页码：165-169
- 全文大小：101 K
文摘
In our joint project involving search of anti-tumor promoters from natural plant sources, six phenylpropanoids and seven phytoquinoids isolated from three Illicium plants (Illiciaceae) were tested for their inhibitory activities against Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All tested compounds showed inhibitory activity against the EBV-EA activation even at 1×10mol ratio, and the inhibitory activity of their compounds was found to be more than that of β-carotene. Two phenylpropanoids having prenyl group, 4-allyl-2-methoxy-6-(3-methyl-2-butenyl)phenol (3) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol (4), showed more potent activities as anti-tumor promoters (IC50 224 and 217mol ratio/TPA, respectively). The presence of a prenyl moiety in the phenylpropanoids plays an important role in anti-tumor promoting activity as xanthone, coumarin and flavonoid previously reported. This investigation indicated that prenylated phenylpropanoids might be valuable as potential cancer chemopreventive agents.