Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
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- 作者：Chihiro Ito ; Masataka Itoigawa ; Tetsufumi Kanematsu ; Yuuki Imamura ; Harukuni Tokuda ; Hoyoku Nishino ; Hiroshi Furukawa
- 关键词：Cinnamylphenols ; Cancer chemopreventive agents ; Anti-tumor promoters ; Epstein-Barr virus activation ; Two-stage mouse skin carcinogenesis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2007
- 出版时间：July 2007
- 年：2007
- 卷：42
- 期：7
- 页码：902-909
- 全文大小：219 K
文摘
Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).