An auxiliary induced asymmetric synthesis of functionalized cyclobutanes by means of catalytic (2+2)-cycloaddition reaction
详细信息 查看全文
- 作者：Takasu ; Kiyosei ; Nagao ; Satoshi ; Ueno ; Megumi ; Ihara ; Masataka
- 关键词：Hydroxycyclobutanes ; (2+2)-Cycloadditions ; Stereoselectivity ; Chiral auxiliary ; Asymmetric induction
- 刊名：Tetrahedron
- 出版年：2004
- 出版时间：February 23, 2004
- 年：2004
- 卷：60
- 期：9
- 页码：2071-2078
- 全文大小：256 K
文摘
A new entry to optically active hydroxycyclobutanes is described. Treatment of silyl enol ether and (−)-8-phenylmenthyl acrylate in the presence of a catalytic amount of EtAlCl2 affords enantiomerically enriched multi-substituted cyclobutane compounds in a good yield and diastereofacial selectivity.