Relationship of parental bonding styles with gray matter volume of dorsolateral prefrontal cortex in young adults

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• 作者：Kosuke Narita ; Yuichi Takei ; Masashi Suda ; Yoshiyuki Aoyama ; Toru Uehara ; Hirotaka Kosaka ; Makoto Amanuma ; Masato Fukuda ; Masahiko Mikuni
• 关键词：Brain development ; Care and overprotection ; Dorsolateral prefrontal cortex ; Parental bonding instrument (PBI) ; Voxel-based morphometry
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2010
• 出版时间：30 May 2010
• 年：2010
• 卷：34
• 期：4
• 页码：624-631
• 全文大小：1683 K

文摘

Previous epidemiologic studies using the parental bonding instrument (PBI), a self-report scale to rate attitudes of parents during the first 16 years, have suggested that a lower parental care score or higher parental overprotection score could lead to an increased risk of several psychiatric disorders, including schizophrenia and mood disorder. However, neuroimaging studies of an association between PBI scores and brain developmental abnormalities are still limited. In this region-of-interest analysis study using a cross-sectional design, we examined 50 normal young adults, in terms of relationships of parental bonding styles during the first 16 years measured by PBI with regional gray matter (GM) volume in the dorsolateral prefrontal cortex (DLPFC). Our study showed that paternal care score positively correlated with the GM volume in the left DLPFC, and paternal and maternal overprotection score negatively correlated with the GM volume in the left DLPFC. In conclusion, our results suggest that in normal young adults, lower paternal care and higher parental overprotection scores correlated with the GM volume reduction in the DLPFC