Sepantronium Bromide (YM155) induces disruption of the ILF3/p54^nrb complex, which is required for survivin expression

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• 作者：Tomohiro Yamauchi ; Naoto Nakamura ; Masashi Hiramoto ; Masatoshi Yuri ; Hiroyuki Yokota ; Masanori Naitou ; Masahiro Takeuchi ; Kentaro Yamanaka ; Aya Kita ; Takahito Nakahara ; Isao Kinoyama ; Akira Matsuhisa ; Naoki Kaneko ; Hiroshi Koutoku ; Masao Sasamata ; Masato Kobori ; Masao Katou ; Shuichi Tawara ; Shigeki Kawabata ; Kiyoshi Furuichi ; et al.
• 关键词：YM155 ; survivin expression ; p54nrb ; ILF3
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 出版时间：7 September, 2012
• 年：2012
• 卷：425
• 期：4
• 页码：711-716
• 全文大小：749 K

文摘

YM155, a small-molecule survivin suppressant, specifically binds to the transcription factor ILF3, which regulates the expression of survivin . In this experiment we have demonstrated that p54^nrb binds to the survivin promoter and regulates survivin expression. p54^nrb forms a complex with ILF3, which directly binds to YM155. YM155 induces disruption of the ILF3/p54^nrb complex, which results in a different subcellular localization between ILF3 and p54^nrb. Thus, identification of molecular targets of YM155 in suppression of the survivin pathway, might lead to development of its use as a novel potential target in cancers.