miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes
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- 作者：Keita Tsujimura1 ; 2 ; Koichiro Irie1 ; Hideyuki Nakashima1 ; Yoshihiro Egashira3 ; Yoichiro Fukao4 ; 9 ; Masayuki Fujiwara4 ; 10 ; Masayuki Itoh5 ; Masahiro Uesaka1 ; Takuya Imamura1 ; Yasukazu Nakahata6 ; Yui Yamashita7 ; Takaya Abe8 ; Shigeo Takamori3 ; Kinichi Nakashima1 ; 2 ; kin1@scb.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 September 2015
- 年：2015
- 卷：12
- 期：11
- 页码：1887-1901
- 全文大小：7187 K
文摘
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MeCP2 facilitates the processing of miR-199a as a component of the Drosha complex
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miR-199a ameliorates RTT neuronal phenotypes and its inhibition blocks MeCP2 function
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miR-199a positively controls mTOR signaling by targeting mTOR signaling inhibitors
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Genetic deletion of miR-199a-2 recapitulates numerous RTT phenotypes