The oxidation of 8-oxo-7,8-dihydroguanine by iodine

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• 作者：Katsuhito Kino ; Masayuki Morikawa ; Teruhiko Kobayashi ; Takanobu Kobayashi ; Rie Komori ; Yoshihisa Sei ; Hiroshi Miyazawa
• 关键词：8oxoG ; Iodine ; Oxidation ; DNA damage
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：15 June 2010
• 年：2010
• 卷：20
• 期：12
• 页码：3818-3820
• 全文大小：251 K

文摘

8-Oxo-7,8-dihydroguanine was specifically oxidized by iodine with aqueous KI. Under acidic conditions, the major product was dehydro-guanidinohydantoin. Under basic conditions, two diastereoisomers of spirohydantoin were chiefly obtained. In addition, unstable diimine was detected for the first time.