Biotransformation of aromatic heterocyclic compounds by Caragana chamlagu and Wasabia japonica

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• 作者：Takamitsu Utsukihara ; Michiko Sato ; Mai Kawamoto ; Ken-ichi Itoh ; Hiroshi Sakamaki ; Masayuki Kuniyoshi ; C. Akira Horiuchi
• 关键词：Oxidative cleavage reactions ; Indole ; Benzofuran ; Caragana chamlagu ; Wasabia japonica
• 刊名：Journal of Molecular Catalysis B: Enzymatic
• 出版年：2007
• 出版时间：24 September 2007
• 年：2007
• 卷：48
• 期：3-4
• 页码：59-63
• 全文大小：289 K

文摘

The biotransformation of several indoles using suspension plant cultured-cells of Caragana chamlagu gave the corresponding ketoamides by oxidative cleavage. In the case of biotransformation of 2,3-dimethylindole (1) by C. chamlagu, o-acetylaminoacetophenone (1b, 76 % ) as the major product and 2,3-epoxy-2,3-dimethylindoline (1a, 11 % ) were obtained after 6 days’ incubation. Furthermore, the biotransformation of 1 in the presence of H₂O₂ gave the compounds 1b (83 % ) and 1a (6 % ) in short time (1 h). On the other hand, the biotransformation of 2,3-dimethylindole (1) for Wasabia japonica (Japanese horseradish)–H₂O₂ system gave o-acetylaminoacetophenone (1b) in good yield. Moreover, we discuss about biotransformation for 2,3-dimethylbenzofuran (11), benzofuran (12), benzoxazole, (13) and 2-methylbenzoxazole (14).