Nocturnal Polyuria and Hypertension in Patients with Lifestyle Related Diseases and Overactive Bladder

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• 作者：Osamu Yokoyama^a ; ^{oyoko@u-fukui.ac.jp} ; Osamu Nishizawa^b ; Yukio Homma^c ; Masayuki Takeda^e ; Momokazu Gotoh^f ; Hidehiro Kakizaki^g ; Hironobu Akino^a ; Koichi Hayashi^d ; Koji Yonemoto^h ; for the OASIS Project Group
• 关键词：urinary bladder ; overactive ; nocturia ; hypertension ; polyuria ; life style
• 刊名：The Journal of Urology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：197
• 期：2
• 页码：423-431
• 全文大小：1560 K
• 卷排序：197

文摘

The objective of this multicenter cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle related diseases and overactive bladder, with special attention to hypertension.Materials and MethodsAfter baseline assessment, patients recorded 24-hour urinary frequency/volume, blood pressure and heart rate for 3 days. They were stratified into 4 groups based on mean blood pressure, including no hypertension, and controllable, untreated and uncontrolled hypertension, respectively.ResultsThe 2,353 eligible patients, who had urinary urgency once or more per week and 1 or more nocturnal toilet visits, were enrolled from 543 sites in Japan. Of these patients complete data, including the 24-hour frequency volume chart, were collected from 1,271. Multivariable analyses showed a statistically significant association of nocturnal polyuria with increasing age (OR 1.04, 95% CI 1.02–1.05, p <0.001) and gender (women vs men OR 0.75, 95% CI 0.59–0.96, p = 0.02), and for controllable (OR 1.10, 95% CI 0.83–1.460), untreated (OR 2.62, 95% CI 1.55–4.45) and uncontrolled (OR 1.15, 95% CI 0.81–1.62) hypertension vs no hypertension (p = 0.005). However, when assessed separately in men and women, hypertension and heart rate were significantly associated with nocturnal polyuria in women alone (p = 0.01 and 0.03, respectively). Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were significantly associated with nocturnal polyuria in men alone (p <0.001).ConclusionsThe current study demonstrates that nocturnal polyuria was significantly associated with age, male gender, and untreated hypertension in patients with lifestyle related diseases and overactive bladder. The association between hypertension and nocturnal polyuria was significant in women alone.