Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
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- 作者：Julian Stingele1 ; Roberto Bellelli1 ; Ferdinand Alte2 ; Graeme Hewitt1 ; Grzegorz Sarek1 ; Sarah L. Maslen3 ; Susan E. Tsutakawa4 ; Annabel Borg1 ; Svend Kjæ ; r1 ; John A. Tainer4 ; 5 ; J. Mark Skehel3 ; Michael Groll2 ; Simon J. Boulton1 ; 6 ; simon.boulton@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA-protein crosslinks ; DNA repair ; DVC1 ; formaldehyde ; hepatocellular carcinoma ; progeria ; protease ; Ruijs-Aalfs syndrome ; SPRTN ; Spartan ; topoisomerase ; Wss1
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：688-703
- 全文大小：3667 K
文摘
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The SPRTN metalloprotease repairs DNA-protein crosslinks
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A DNA switch controls SPRTN’s protease activity
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A ubiquitin switch controls chromatin access of SPRTN
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Structural insights reveal unique features of the SPRTN/Wss1 protease family