Le syndrome des antisynthétases

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• 作者：Imbert-Masseau ; Agathe ; Hamidou ; Mohamed ; Agard ; Christian ; Grolleau ; Jean-Yves ; Ché ; rin ; Pascal
• 关键词：Syndrome des antisynthé ; tases ; Anti-Jo1 ; Fibrose pulmonaire ; Myopathie inflammatoire ; Antisynthetasis syndrome ; Anti-Jo1 ; Interstitial lung disease ; Inflammatory myopathy
• 刊名：Revue du Rhumatisme
• 出版年：2003
• 出版时间：May, 2003
• 年：2003
• 卷：70
• 期：5
• 页码：363-370
• 全文大小：192 K

文摘

The antisynthetase syndrome is caracterized by the severity of the interstitial lung disease. Actually, 7 antibodies from the antisynthetase’s family have been identified. The anti-Jo1 antibody(histidyl tRNA synthetase) is the most usual and associate interstitial lung disease with idiopathic inflammatory myopathy and generally fever, arthritis, Raynaud’s phenomenon and “mechanic’s hand”. The interstitial lung disease of Sas has the same features than idiopathic pulmonary fibrosis and systemic sclerosis, usually of “usual interstitial pneumonia” type. Corticosteroid treatement has usually no efficacy on pulmonary disease and other immunosuppressive drugs are often necessary.