Hodgkin lymphoma in a mutated ZAP-70 negative B-cell Chronic Lymphocytic Leukemia patient
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- 作者：Pasquale Niscola ; Maria Ilaria Del Principe ; Massimiliano Palombi ; Stefano Fratoni ; Daniela Piccioni ; Luca Maurillo ; Paolo de Fabritiis ; Sergio Amadori ; Giovanni Del Poeta
- 关键词：Rituximab ; Imatinib ; CML ; NHL
- 刊名：Leukemia Research
- 出版年：2008
- 出版时间：February 2008
- 年：2008
- 卷：32
- 期：2
- 页码：363-365
- 全文大小：977 K
文摘
Philadelphia positive (Ph+) chronic myeloid leukaemia (CML) presenting synchronously or following non-Hodgkin lymphoma (NHL) has only rarely been reported. Herein, we refer on a case of Ph+ CML occurring after a breast cancer and a NHL with multiple relapses. After obtaining complete cytogenetic remission with imatinib, the patient presented a new NHL relapse, that was treated with rituximab concomitantly to imatinib.
Therapy was well tolerated and the patient is presently alive in complete remission of either NHL and CML. We also reviewed the literature relating the uncommon association of these two unrelated diseases.