Monoelectronic reduction of dihydroartemsisinin (DHA): pH dependence and product analysis
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- 作者：Maria Luisa Navacchia ; Massimo L. Capobianco ; Mila D¡¯Angelantonio ; Giancarlo Marconi
- 关键词：Dihydroartemisinin ; Malaria ; ¦Ã-Radiolysis ; Reduction ; Alkoxyl radicals
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：18 September, 2013
- 年：2013
- 卷：54
- 期：38
- 页码：5257-5260
- 全文大小：556 K
文摘
The reaction of dihydroartemisinin (DHA) with solvated electrons () generated under radiolytic conditions showed high pH dependence. The reduction performed under neutral conditions led to the formation of compound P1 deriving from the initial alkoxyl radical as the only detectable product.