Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial

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• 作者：Fulvio Zullo ; Stefano Palomba ; Angela Falbo ; Tiziana Russo ; Rita Mocciaro ; Eduardo Tartaglia ; Piers ; ro Tagliaferri ; Pasquale Mastrantonio
• 关键词：endometrial cancer ; laparoscopy ; laparotomy ; surgery ; uterine cancer
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：200
• 期：3
• 页码：296.e1-296.e9
• 全文大小：405 K

文摘

Objective

The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer.

Study Design

This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stage I endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle.

Results

After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0 % ] and 7/38 [18.4 % ]; P = .860) and deaths (7/40 [17.5 % ] and 6/38 [15.8 % ] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed.

Conclusion

The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.