- 作者：Stefano Palomba ; M.D.a ; stefanopalomba@tin.it ; Angela Falbo ; M.D.a ; Laura Carrillo ; M.D.b ; Maria Teresa Villani ; M.D.c ; Francesco Orio ; M.D.d ; Tiziana Russo ; M.D.a ; Annalisa Di Cello ; M.D.a ; Fulvio Cappiello ; M.D.e ; Sabina Capasso ; M.D.e ; Achille Tolino ; M.D.f ; Annamaria Colao ; M.D.g ; Pasquale Mastrantonio ; M.D.h ; Giovanni Battista La Sala ; M.D.c ; Fulvio Zullo ; M.D.a ; Ettore Cittadini ; M.D.b ; The METformin in High Responder Italian Group
- 关键词：Gonadotropins ; infertility ; IVF ; metformin ; OHSS ; PCOS ; sterility
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：December, 2011
- 年：2011
- 卷：96
- 期：6
- 页码：1384-1390.e4
- 全文大小：357 K
Objective
To test whether metformin administration reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovary syndrome (PCOS) who have been treated with gonadotropins for IVF.Design
Parallel, randomized, double-blind, placebo-controlled clinical trial.
Setting
Academic departments, general hospital, and IVF centers.
Patient(s)
One hundred twenty patients with PCOS at high risk for OHSS.
Intervention(s)
Gonadotropins ovarian stimulation for IVF and metformin (500 mg three times daily) or placebo tablets (three times daily).
Main Outcome Measure(s)
The primary end point of the current clinical trial was the rate of OHSS. Anthropometric and reproductive data were evaluated.
Result(s)
The total OHSS and cancellation rates were significantly reduced in patients treated with metformin. The relative risk for OHSS was of 0.28 (95 % confidence interval, 0.11-0.67). With metformin the stimulation length and the total amount of gonadotropins used were significantly increased, whereas the peak E2 levels were significantly reduced.
Conclusion(s)
In patients with PCOS who are at high risk for OHSS and who have been stimulated with gonadotropins for IVF cycles, metformin reduces the risk of OHSS by modulating the ovarian response to the stimulation.
Registration ID number from clinicaltrials.gov
NCT01233206.