Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia
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- 作者：Glauce N. Silva ; Fabí ; ola R. Martins ; Maria Eline Matheus ; Suzana G. Leitã ; o and Patricia D. Fernandes
- 关键词：Lantana trifolia ; Verbenaceae ; Antinociceptive activity ; Anti-inflammatory activity ; Medicinal plant
- 刊名：Journal of Ethnopharmacology
- 出版年：2005
- 出版时间：2005
- 年：2005
- 卷：100
- 期：3
- 页码：254-259
- 全文大小：234 K
文摘
The anti-inflammatory activity of Lantana trifolia (Verbenaceae) was determined by carrageenan, serotonin and histamine-induced rat paw edema and the analgesic activity of this plant was studied by acetic acid-induced writhings and tail flick tests in mice. Lantana trifolia extracts (at 30 mg/kg) inhibited carrageenan and histamine-induced rat paw edema. Although the extracts did not produce any effect on acetic acid-induced writhings, they all develop a significant increase on tail flick antinociceptive index (doses varying between 1 and 30 mg/kg), indicating a spinal antinociceptive effect. These results provide support for the use of Lantana trifolia in relieving inflammatory pain.