Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets
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- 作者：Kristen Uchtmann ; Electa R. Park ; Alexis Bergsma ; Justin Segula ; Mathew J. Edick ; Cindy K. Miranti ; cindy.miranti@vai.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tetraspanins ; Integrins ; Blood platelets ; Cell adhesion ; Disease model-animals
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：10 December 2015
- 年：2015
- 卷：339
- 期：2
- 页码：261-269
- 全文大小：2359 K
文摘
First report on the function of tetraspanin CD82 in platelets.
CD82 knockout in mice reduces bleeding time in vivo.
CD82 loss intrinsically enhances platelet-mediated clot retraction in vitro.
CD82 suppresses integrin αIIbβ3 expression.
CD82 suppresses adhesion and tyrosine kinase signaling on fibrinogen.