Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo
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- 作者：Mathew M. Loescha ; 1 ; Ann E. Collierb ; David H. Southerna ; Rachel E. Warda ; Sunil S. Tholpadyc ; d ; Davina A. Lewisa ; 2 ; Jeffrey B. Traversa ; d ; 3 ; Dan F. Spandaua ; b ; dspanda@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：IGF-1R ; NER ; Keratinocyte ; UVB ; Xenograft
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：10
- 期：8
- 页码：1245-1254
- 全文大小：1634 K
文摘
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IGF-1R is necessary for optimal repair of UVB-induced DNA damage in keratinocytes.
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Novel separation technique allows study specifically in basal layer keratinocytes.
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IGF-1R activation enhances the expression of nucleotide excision repair genes.