A convenient route to [⁶⁸Ga]Ga-MAA for use as a particulate PET perfusion tracer

详细信息    查看全文

• 作者：Carla J. Mathias ; Mark A. Green
• 关键词：Gallium-68 ; Macroaggregated human serum albumin (MAA) ; PET ; Perfusion
• 刊名：Applied Radiation and Isotopes
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：66
• 期：12
• 页码：1910-1912
• 全文大小：279 K

文摘

A convenient method is described for compounding [⁶⁸Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO₂-based ⁶⁸Ge/⁶⁸Ga generator. The final [⁶⁸Ga]Ga-MAA product was obtained with an 81.6±5.3 % decay-corrected radiochemical yield and a radiochemical purity of 99.8±0.1 % (n=5). Microscopic examination showed the [⁶⁸Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [⁶⁸Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4±0.9 % of the total ⁶⁸Ge breakthrough remaining associated with the final [⁶⁸Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [⁶⁸Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.