Quantification of left and right ventricular function and myocardial mass: Comparison of low-radiation dose 2nd generation dual-source CT and cardiac MRI

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• 作者：Richard A.P. Takx^a ; ^b ; ^{takx@student.maastrichtuniversity.nl} ; Antonio Moscariello^a ; ^c ; ^{moscarie@musc.edu} ; U. Joseph Schoepf^a ; ^{schoepf@musc.edu} ; J. Michael Barraza Jr.^a ; ^{barraza@musc.edu} ; John W. Nance Jr.^a ; ^{nancej@musc.edu} ; Gorka Bastarrika^a ; ^d ; ^{bastarrika@unav.es} ; Marco Das^b ; ^{m.das@mumc.nl} ; Mathias Meyer^a ; ^e ; ^{mr.meyer.mathias@gmail.com} ; Joachim E. Wildberger^b ; ^{j.wildberger@mumc.nl} ; Stefan O. Schoenberg^e ; ^{stefan.schoenberg@umm.de} ; Christian Fink^e ; ^{christian.fink@umm.de} ; Thomas Henzler^a ; ^e ; ^{thomas.henzler@umm.de}
• 关键词：DSCT ; Cardiac CT ; Cardiac MRI ; Myocardial mass ; Cardiac function
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：81
• 期：4
• 页码：e598-e604
• 全文大小：617 K

文摘

Objective

To prospectively evaluate the accuracy of left and right ventricular function and myocardial mass measurements based on a dual-step, low radiation dose protocol with prospectively ECG-triggered 2nd generation dual-source CT (DSCT), using cardiac MRI (cMRI) as the reference standard.

Materials and methods

Twenty patients underwent 1.5 T cMRI and prospectively ECG-triggered dual-step pulsing cardiac DSCT. This image acquisition mode performs low-radiation (20 % tube current) imaging over the majority of the cardiac cycle and applies full radiation only during a single adjustable phase. Full-radiation-phase images were used to assess cardiac morphology, while low-radiation-phase images were used to measure left and right ventricular function and mass. Quantitative CT measurements based on contiguous multiphase short-axis reconstructions from the axial CT data were compared with short-axis SSFP cardiac cine MRI. Contours were manually traced around the ventricular borders for calculation of left and right ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass for both modalities. Statistical methods included independent t-tests, the Mann-Whitney U test, Pearson correlation statistics, and Bland-Altman analysis.

Results

All CT measurements of left and right ventricular function and mass correlated well with those from cMRI: for left/right end-diastolic volume r = 0.885/0.801, left/right end-systolic volume r = 0.947/0.879, left/right stroke volume r = 0.620/0.697, left/right ejection fraction r = 0.869/0.751, and left/right myocardial mass r = 0.959/0.702. Mean radiation dose was 6.2 ¡À 1.8 mSv.

Conclusions

Prospectively ECG-triggered, dual-step pulsing cardiac DSCT accurately quantifies left and right ventricular function and myocardial mass in comparison with cMRI with substantially lower radiation exposure than reported for traditional retrospective ECG-gating.