Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis

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• 作者：Han Zheng^a ; Marí ; a C. Domí ; nguez Punaro^b ; Mariela Segura^b ; Claude Lachance^b ; Serge Rivest^c ; Jianguo Xu^a ; Mathieu Houde^b ; Marcelo Gottschalk^b ; ^{marcelo.gottschalk@umontreal.ca"" rel=""nofollow}
• 关键词：Streptococcus suis ; Meningitis ; Astrocytes ; Cytokines ; TLR2
• 刊名：Journal of Neuroimmunology
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：234
• 期：1-2
• 页码：71-83
• 全文大小：1631 K

文摘

The murine astrocyte response to virulent Streptocuccus suis, a swine and an emerging human meningitis-causing pathogen, is reported. Albeit astrocytes do not internalize S. suis, all S. suis strains studied enhanced Toll-like receptor (TLR)2 expression and the production of pro-inflammatory cytokines and inducible nitric oxide synthase. Cell wall components and hemolysin (suilysin) are shown to be mainly responsible for cell activation. Astrocytes from TLR2 knockout mice presented a partial but significant reduction of S. suis-induced production of pro-inflammatory cytokines. These results contribute to increase the knowledge on mechanisms underlying S. suis inflammation in the brain.