Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: A longitudinal small animal PET study using [18F]MK-9470
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- 作者：Mathieu Verduranda ; b ; c ; 1 ; verdurand@cermep.fr" class="auth_mail ; Victoria S. Daltona ; b ; d ; 2 ; daltonv@tcd.ie" class="auth_mail ; Vu Nguyenb ; 3 ; vhn@ansto.gov.au" class="auth_mail ; Marie-Claude Gré ; goireb ; 3 ; mcg@ansto.gov.au" class="auth_mail ; David Zahrab ; 3 ; dzx@ansto.gov.au" class="auth_mail ; Naomi Wyattb ; 3 ; naomi.wyatt@ansto.gov.au" class="auth_mail ; Leena Burgessb ; 3 ; lbs@ansto.gov.au" class="auth_mail ; Ivan Greguricb ; 3 ; ivg@ansto.gov.au" class="auth_mail ; Katerina Zavitsanoua ; b ; e ; f ; k.zavitsanou@neura.edu.au" class="auth_mail
- 关键词：Poly I ; C ; Maternal immune activation ; CB1 receptors ; Schizophrenia ; PET imaging ; Neurodevelopment ; [18F]MK-9470
- 刊名：Experimental Neurology
- 出版年：July 2014
- 年：2014
- 卷：257
- 期：Complete
- 页码：162-169
- 全文大小：725 K
文摘
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We model viral infection in pregnancy (a schizophrenia risk factor) in rats.
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We look at the impact of prenatal poly I:C on CB1 receptors (CB1Rs) in offspring.
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We image CB1Rs longitudinally with Positron Emission Tomography and [18F]MK-9470.
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Prenatal poly I:C leads to alterations in CB1Rs in offspring that are age-specific.
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CB1Rs are increased in adulthood mirroring changes found in schizophrenia patients.