Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups
详细信息 查看全文
- 作者：Cyrille Lescop ; cyrille.lescop@actelion.com" class="auth_mail" title="E-mail the corresponding author ; Claus Mü ; ller ; Boris Mathys ; Magdalena Birker ; Ruben de Kanter ; Christopher Kohl ; Patrick Hess ; Oliver Nayler ; Markus Rey ; Patrick Sieber ; Beat Steiner ; Thomas Weller ; Martin H. Bolli
- 关键词：S1P1 receptor agonist ; Immunomodulator ; Lymphocyte count ; Aminomethyl pyridine ; Aminomethyl benzene ; Aminomethyl thiophene ; Phototoxicity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：116
- 期：Complete
- 页码：222-238
- 全文大小：3653 K
文摘
- •
A new class of potent and selective S1P1 receptor agonists was identified.
- •
Alkylaminomethyl substituted aryl compounds exhibited nanomolar affinity for S1PR1.
- •
These S1P1 receptor agonists, such as
- •
The new S1PR1 agonist series showed no in vitro phototoxicity.