Prognostic Factors in Resected Pancreatic Neuroendocrine Tumours: Experience in 95 Patients

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• 作者：Francisco Sá ; nchez-Bueno^a ; ^{sbuenof@um.es" class="auth_mail" title="E-mail the corresponding author} ; José ; Manuel Rodr&iacute ; guez Gonzá ; lez^a ; Gloria Torres Salmeró ; n^a ; Antonio Bernabé ; Peñ ; alver^a ; Mar&iacute ; a Balsalobre Salmeron^a ; Jesú ; s de la Peñ ; a Moral^b ; Matilde Fuster Quiñ ; onero^c ; Pascual Parrilla Paricio^a
• 关键词：Pancreas ; Pancreatic neuroendocrine tumours ; Pancreatic resection ; Insulinomas ; Gastrinomas ; Glucagonomas
• 刊名：Cirugía Española (English Edition)
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：94
• 期：8
• 页码：473-480
• 全文大小：710 K

文摘

The aim of this study was to analyse prognostic factors for survival and recurrence in patients with resected pancreatic neuroendocrine tumours (PNT).

Methods

Medical records of 95 patients with resected PNT were retrospectively reviewed. The variables studied were: age, sex, form of presentation (sporadic/familial tumours), functionality, type of tumour, localisation, type of surgery, tumour size, multifocal tumours and recurrent rate. The new WHO classification (2010) was used.

Results

There were 45 men and 50 women. Mean age was 46.8 years. Regarding the mode of presentation, it was sporadic in 66 patients (69.8%) and 29 cases were familial neuroendocrine tumours (30.2%) in association with MEN 1 syndrome. The 59% of patients suffered from non-functional tumours and 41% were functional: 20 insulinoma, 16 gastrinoma, and 3 glucagonoma. Distal pancreatectomy was the most common surgical procedure, followed by tumour enucleation in 19 patients. According to the WHO classification, 59 patients had a PNT G1, 24 PNT G2 and 12 with a poorly-differentiated carcinoma, respectively. The 5-year survival in well-differentiated tumours was 100%, regardless of the functionality. Sporadic PNT are more commonly unifocal (P<.001), associating liver metastasis. Survival and recurrence rates after a mean follow-up of 85.3 months were 65.8% and 24%, respectively.

Conclusions

In our experience, WHO classification was an independent prognostic factor in PNT survival.