Correlation between number of renal cysts and aortic circumferences measured using autopsy material

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• 作者：Atsushi Kurata ; Shigeru Inoue ; Shin-ichiro Ohno ; Ryosuke Nakatsubo ; Kengo Takahashi ; Tatsuya Ito ; Kenta Kawasaki ; Reiji Kokubo ; Takashi Sakai ; Jun Ubukata ; Shuya Matsubara ; Ryu Muraoka ; Jun Yamazaki ; Takao Hirose ; Mayuko Hojo ; Eri Watanabe ; Masahiko Kuroda
• 关键词：Aneurysm ; Aorta ; Renal cyst ; Basement membrane ; Autopsy
• 刊名：Pathology - Research and Practice
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：209
• 期：7
• 页码：441-447
• 全文大小：1581 K

文摘

Although the presence of renal cysts has been reported to be associated with aortic aneurysm or dissection by imaging studies, an autopsy study has not been performed. Therefore, in our institute, recent consecutive adult autopsy cases (n = 108, 64 males and 44 females) were reviewed. The circumferences and atherosclerosis ratios of both thoracic and abdominal aorta were individually measured and graded. The number of renal cysts was scored and graded. Age of subjects along with histories of smoking, hypertension, and diabetes mellitus were confirmed. Multiple linear regression analyses demonstrated that severity of atherosclerosis and the number of renal cysts were correlated with thoracic aortic circumference, while only the number of renal cysts was correlated with abdominal aortic circumference (p < 0.05), which was more predominant in female subjects (p < 0.05). Microscopically, significantly more dilated renal tubules (by Student's t-test, p < 0.05) along with decreased stainability of basement membrane by Periodic acid-Schiff staining and immunostaining of type IV collagen were noted in background renal tissues in cases with numerous renal cysts than in age- and sex-matched controls without renal cysts (n = 10 vs. 10). The present study suggests that a syndrome that affects both aorta and renal tubules may exist.