Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals
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- 作者：Fumiya Tatsuki1 ; 5 ; Genshiro A. Sunagawa2 ; 5 ; Shoi Shi1 ; 5 ; Etsuo A. Susaki1 ; 2 ; 5 ; Hiroko Yukinaga2 ; 5 ; Dimitri Perrin2 ; 4 ; 5 ; Kenta Sumiyama3 ; Maki Ukai-Tadenuma2 ; Hiroshi Fujishima2 ; Rei-ichiro Ohno1 ; Daisuke Tone1 ; Koji L. Ode1 ; 2 ; Katsuhiko Matsumoto2 ; Hiroki R. Ueda1 ; 2 ; uedah-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 April 2016
- 年：2016
- 卷：90
- 期：1
- 页码：70-85
- 全文大小：4950 K
文摘
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A simple model predicts Ca2+-dependent hyperpolarization regulates sleep duration
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Impaired/enhanced Ca2+-dependent hyperpolarization decreases/increases sleep duration
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Impaired Ca2+-dependent hyperpolarization increases neural excitability
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Impaired Ca2+/calmodulin-dependent kinases (Camk2a/Camk2b) decreases sleep duration