Endothelial dysfunction and cardiovascular risk factors in childhood acute lymphoblastic leukemia survivors

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• 作者：Paola Giordano^a ; ¹ ; Paola Muggeo^a ; ¹ ; ^{paola.muggeo@tiscali.it} ; Maurizio Delvecchio^a ; ¹ ; Santa Carbonara^b ; ¹ ; Alberto Romano^a ; ¹ ; Maria Altomare^a ; ¹ ; Gabriella Ricci^b ; ¹ ; Federica Valente^b ; ¹ ; Annapaola Zito^b ; ¹ ; Pietro Scicchitano^b ; ² ; Luciano Cavallo^a ; ¹ ; Marco Matteo Ciccone^b ; ¹ ; Nicola Santoro^a ; ¹ ; ³ ; Maria Felicia Faienza^a ; ¹ ; ³
• 关键词：ALL ; acute lymphoblastic leukemia ; FMD ; flow-mediated dilation ; C-IMT ; common carotid intima-media thickness ; APAO ; antero-posterior diameter of infra-renal abdominal aorta ; CVD ; cardiovascular disease ; AIEOP ; Italian Association of Pediatric Hematology and Oncology ; BFM ; Berlin&ndash ; Frankfurt&ndash ; Munster group (for diagnosis and treatment of leukemia) ; TC ; total cholesterol ; TG ; triglycerides ; LDL-C ; low density lipoprotein cholesterol ; HDL-C ; high density lipoprotein cholesterol ; hs-CRP ; hi
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：621-627
• 全文大小：272 K
• 卷排序：228

文摘

Childhood ALL survivors show vascular endothelial dysfunction. They show cardiovascular alterations even though obesity is not documented. Vascular dysfunction is expresses by reduction of FMD and of biomarkers (AD/HMW-AD) AD/HMW-AD and FMD detect preclinical metabolic and CV disease in ALL patients. Pharmacological strategies targeting endothelial dysfunction are intriguing.