Internalization and Mechanism of Action of Clostridial Toxins in Neurons

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• 作者：Carlotta Grumelli ; Claudia Verderio ; Davide Pozzi ; Ornella Rossetto ; Cesare Montecucco and Michela Matteoli
• 关键词：Botulinum toxins ; SNAREs ; Hippocampal neurons ; Interneurons
• 刊名：Neurotoxicology
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：26
• 期：5
• 页码：761-767
• 全文大小：226 K

文摘

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.