Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina
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- 作者：Helen L. May-Simera1 ; 6 ; 7 ; hmaysime@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Jessica D. Gumerson1 ; Chun Gao1 ; Maria Campos1 ; Stephanie M. Cologna2 ; Tina Beyer3 ; Karsten Boldt3 ; Koray D. Kaya1 ; Nisha Patel1 ; Friedrich Kretschmer1 ; Matthew W. Kelley4 ; Ronald S. Petralia4 ; Megan G. Davey5 ; Tiansen Li1 ; tiansen.li@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：retina ; cilia ; ciliogenesis ; ciliopathy ; polarity ; retinal degeneration ; basal body ; centrosome ; microtubule ; actin
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：17
- 期：5
- 页码：1399-1413
- 全文大小：8808 K
文摘
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MACF1 is required for apical basal body docking and ciliogenesis
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MACF1 is critical for maintenance of the photoreceptor sensory cilium
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Primary cilia may provide positional cues for apicobasal polarization of photoreceptors