Redox dynamics of manganese as a mitochondrial life-death switch

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• 作者：Matthew Ryan Smith¹ ; Jolyn Fernandes¹ ; Young-Mi Go ; Dean P. Jones ; ^{dpjones@emory.edu}
• 关键词：Heavy metal ; Hydrogen peroxide ; MnSOD ; Neurodegenerative disease ; Nutritional metal ; Redox state
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：388-398
• 全文大小：1866 K
• 卷排序：482

文摘

Either insufficient or excess manganese activates mitochondria-mediated cell death. The optimal healthy Mn exposure window is very narrow. Mitochondrial H2O2 production depends on Mn across physiologic to toxicologic range. Integrative omics needed to understand complex Mn interaction in cell fate. Mn is central to redox interface between an organism and its environment.