Effect of Treatment of Obstructive Sleep Apnea on Seizure Outcomes in Children With Epilepsy

详细信息    查看全文

• 作者：Eric Segal ; MD ; Martina Vendrame ; MD ; PhD ; Matthew Gregas ; PhD ; Tobias Loddenkemper ; MD ; Sanjeev V. Kothare ; MD ; ^{sanjeev.kothare@childrens.harvard.edu}
• 刊名：Pediatric Neurology
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：46
• 期：6
• 页码：359-362
• 全文大小：109 K

文摘

A retrospective review of children with epilepsy and obstructive sleep apnea, treated surgically for their obstructive sleep apnea from January 2008-October 2010, was performed for age, sex, type of epilepsy, antiseizure medications, sleep-study data, and changes in seizure frequency. Twenty-seven subjects (median age, 5 years) with no adjustment to their medications around their time of surgery were identified. Three months after surgery, 10 (37 % ) patients became seizure-free, three (11 % ) demonstrated >50 % seizure-reduction, and six (22 % ) exhibited an amelioration of seizure frequency. Two (7 % ) demonstrated unchanged seizure-frequency, and six (22 % ) manifested a worsening of seizure frequency. Median seizure frequency before surgery was 8.5 (interquartile range, 2-90), and after surgery, three (interquartile range, 0-75), with a 53 % median seizure reduction. Multivariate analysis demonstrated a trend toward seizure freedom with each percentile increase in body mass index and early age of surgery. We conclude that obstructive sleep apnea surgery may decrease seizure frequency, especially in children with elevated body mass index scores and younger age at time of surgery.